|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Chicken|
|Dilution||IHC-P (1:100), WB (1:1000),|
|Other Names||Periostin, PN, Osteoblast-specific factor 2, OSF-2, POSTN, OSF2|
|Target/Specificity||Based on the homology of the immunogen with other species, we expect that this antibody will recognize periostin in most, if not all, species of mammals, birds, amphibians, and fishes. Specific for three periostin bands around ~93 kDa in mouse lung e ...|
|Reconstitution & Storage||Store at -20°C. Aliquot to avoid freeze/thaw cycles. Store undiluted.|
|Precautions||POSTN / Periostin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.|
|Cellular Location||Golgi apparatus. Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi.|
|Tissue Location||Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor Overexpressed in breast cancers.|
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Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.
Takeshita S.,et al.Biochem. J. 294:271-278(1993).
Gillan L.,et al.Cancer Res. 62:5358-5364(2002).
Bai Y.,et al.Jpn. Clin. Med. 1:13-20(2010).
Yamada S.,et al.Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
Dunham A.,et al.Nature 428:522-528(2004).
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