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POSTN / Periostin Antibody

Rabbit Polyclonal Antibody

     
  • IHC - POSTN / Periostin Antibody ALS16118
    Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q15063
Reactivity Human, Mouse, Rat, Chicken
Host Rabbit
Clonality Polyclonal
Calculated MW 93kDa
Dilution IHC-P (1:100), WB (1:1000),
Additional Information
Gene ID 10631
Other Names Periostin, PN, Osteoblast-specific factor 2, OSF-2, POSTN, OSF2
Target/Specificity Based on the homology of the immunogen with other species, we expect that this antibody will recognize periostin in most, if not all, species of mammals, birds, amphibians, and fishes. Specific for three periostin bands around ~93 kDa in mouse lung e ...
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles. Store undiluted.
PrecautionsPOSTN / Periostin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name POSTN
Synonyms OSF2
Function Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.
Cellular Location Golgi apparatus. Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi.
Tissue Location Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor Overexpressed in breast cancers.
Volume 50 µl
Research Areas
Citations (0)

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Background

Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.

References

Takeshita S.,et al.Biochem. J. 294:271-278(1993).
Gillan L.,et al.Cancer Res. 62:5358-5364(2002).
Bai Y.,et al.Jpn. Clin. Med. 1:13-20(2010).
Yamada S.,et al.Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
Dunham A.,et al.Nature 428:522-528(2004).

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$ 395.00
Cat# ALS16118
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