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TSG / TWSG1 Antibody (clone 2F3)

Mouse Monoclonal Antibody

     
  • IHC - TSG / TWSG1 Antibody (clone 2F3) ALS16120
    Anti-TSG / TWSG1 antibody IHC staining of human brain, cortex.
  • WB - TSG / TWSG1 Antibody (clone 2F3) ALS16120
    TWSG1 monoclonal antibody (M07), clone 2F3. Western blot of TWSG1 expression in human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9GZX9
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2F3
Calculated MW 25kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 57045
Other Names Twisted gastrulation protein homolog 1, TWSG1, TSG
Target/Specificity Human TWSG1
Reconstitution & Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsTSG / TWSG1 Antibody (clone 2F3) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TWSG1
Synonyms TSG
Function May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).
Cellular Location Secreted.
Volume 50 µl
Research Areas
Citations (0)

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Background

May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).

References

Scott I.C.,et al.Nature 410:475-478(2001).
Scott I.C.,et al.Nature 411:720-720(2001).
Graf D.,et al.Mamm. Genome 12:554-560(2001).
Li J.M.,et al.Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 450.00
Cat# ALS16120
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