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TSG / TWSG1 Antibody (clone 2F3)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9GZX9 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2F3 |
| Calculated MW | 25kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 57045 |
|---|---|
| Other Names | Twisted gastrulation protein homolog 1, TWSG1, TSG |
| Target/Specificity | Human TWSG1 |
| Reconstitution & Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TSG / TWSG1 Antibody (clone 2F3) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TWSG1 |
|---|---|
| Synonyms | TSG |
| Function | May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). |
| Cellular Location | Secreted. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).
References
Scott I.C.,et al.Nature 410:475-478(2001).
Scott I.C.,et al.Nature 411:720-720(2001).
Graf D.,et al.Mamm. Genome 12:554-560(2001).
Li J.M.,et al.Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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