|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (5 µg/ml), WB (0.1-1 µg/ml)|
|Other Names||Multidrug and toxin extrusion protein 2, MATE-2, hMATE-2, Kidney-specific H(+)/organic cation antiporter, Solute carrier family 47 member 2, SLC47A2, MATE2|
|Target/Specificity||Human SLC47A2. This antibody is expected to recognize both reported isoforms (NP_690872.2; NP_001093116.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||SLC47A2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Localized at the brush border membranes of the proximal tubules|
|Tissue Location||Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain|
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Provided below are standard protocols that you may find useful for product applications.
Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.
Masuda S.,et al.J. Am. Soc. Nephrol. 17:2127-2135(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Omote H.,et al.Trends Pharmacol. Sci. 27:587-593(2006).
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