SLC47A2 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q86VL8 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 65kDa |
Dilution | ELISA (1:32000), IHC-P (5 µg/ml), WB (0.1-1 µg/ml) |
Gene ID | 146802 |
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Other Names | Multidrug and toxin extrusion protein 2, MATE-2, hMATE-2, Kidney-specific H(+)/organic cation antiporter, Solute carrier family 47 member 2, SLC47A2, MATE2 |
Target/Specificity | Human SLC47A2. This antibody is expected to recognize both reported isoforms (NP_690872.2; NP_001093116.1). |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | SLC47A2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC47A2 (HGNC:26439) |
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Synonyms | MATE2 |
Function | Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney. |
Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Detected in the renal urinary tubules. |
Tissue Location | [Isoform 1]: High expression in kidney. Very small expression in adrenal gland and lung. [Isoform 6]: Ubiquitously expressed in all tissues examined except the kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.
References
Masuda S.,et al.J. Am. Soc. Nephrol. 17:2127-2135(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Omote H.,et al.Trends Pharmacol. Sci. 27:587-593(2006).
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