|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (5 µg/ml), WB (0.1-1 µg/ml)|
|Other Names||Multidrug and toxin extrusion protein 2, MATE-2, hMATE-2, Kidney-specific H(+)/organic cation antiporter, Solute carrier family 47 member 2, SLC47A2, MATE2|
|Target/Specificity||Human SLC47A2. This antibody is expected to recognize both reported isoforms (NP_690872.2; NP_001093116.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||SLC47A2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Localized at the brush border membranes of the proximal tubules|
|Tissue Location||Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.
Masuda S.,et al.J. Am. Soc. Nephrol. 17:2127-2135(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Omote H.,et al.Trends Pharmacol. Sci. 27:587-593(2006).
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