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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CXCL10 / IP-10 Antibody (aa22-98)   

CXCL10 / IP-10 Antibody (aa22-98)

Rabbit Polyclonal Antibody

     
  • WB - CXCL10 / IP-10 Antibody (aa22-98) ALS16131
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P02778
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 11kDa
Dilution ELISA (1:20000-1:80000), IHC-P (2.5 µg/ml), WB (1:1000-1:2000)
Additional Information
Gene ID 3627
Other Names C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, Gamma-IP10, IP-10, Small-inducible cytokine B10, CXCL10(1-73), CXCL10, INP10, SCYB10
Target/Specificity Human IP-10 / CXCL10.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsCXCL10 / IP-10 Antibody (aa22-98) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CXCL10
Synonyms INP10, SCYB10
Function Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).
Cellular Location Secreted.
Tissue Location Mainly secreted by monocytes, endothelial cells as well as fibroblasts. Expressed by epithelial cells in thymus (PubMed:11157474). Microglial cells produce CXCL10 in response to viral stimulation (PubMed:12663757).
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.

References

Luster A.D.,et al.Nature 315:672-676(1985).
Proost P.,et al.J. Immunol. 150:1000-1010(1993).
Tensen C.P.,et al.J. Invest. Dermatol. 112:716-722(1999).
Hensbergen P.J.,et al.Eur. J. Biochem. 268:4992-4999(2001).
Loos T.,et al.Blood 112:2648-2656(2008).

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Discontinued
Cat# ALS16131
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