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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ENPP2 / Autotaxin Antibody (aa698-712)   

ENPP2 / Autotaxin Antibody (aa698-712)

Goat Polyclonal Antibody

     
  • WB - ENPP2 / Autotaxin Antibody (aa698-712) ALS16150
    ENPP2 antibody (0.3 ug/ml) staining of Human Placenta lysate (35 ug protein in RIPA buffer).
  • IHC - ENPP2 / Autotaxin Antibody (aa698-712) ALS16150
    Anti-ENPP2 / Autotaxin antibody IHC staining of human brain, cortex.
  • IHC - ENPP2 / Autotaxin Antibody (aa698-712) ALS16150
    Anti-ENPP2 / Autotaxin antibody IHC staining of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q13822
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 99kDa
Dilution ELISA (1:128000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 5168
Other Names Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, E-NPP 2, 3.1.4.39, Autotaxin, Extracellular lysophospholipase D, LysoPLD, ENPP2, ATX, PDNP2
Target/Specificity Human ENPP2 / Autotaxin. This antibody is expected to recognize all reported isoforms (NP_006200.3; NP_001035181.1, NP_001124335.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsENPP2 / Autotaxin Antibody (aa698-712) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ENPP2
Synonyms ATX, PDNP2
Function Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
Cellular Location Secreted. Note=Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells
Tissue Location Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues
Research Areas
Citations (0)

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Background

Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.

References

Murata J.,et al.J. Biol. Chem. 269:30479-30484(1994).
Kawagoe H.,et al.Genomics 30:380-384(1995).
Lee H.Y.,et al.Biochem. Biophys. Res. Commun. 218:714-719(1996).
van Meeteren L.A.,et al.J. Biol. Chem. 280:21155-21161(2005).
Giganti A.,et al.J. Biol. Chem. 283:7776-7789(2008).

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$ 395.00
Cat# ALS16150
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