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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KLK6 / Kallikrein 6 Antibody (aa145-156)   

KLK6 / Kallikrein 6 Antibody (aa145-156)

Goat Polyclonal Antibody

     
  • IHC - KLK6 / Kallikrein 6 Antibody (aa145-156) ALS16151
    Anti-KLK6 / Kallikrein 6 antibody IHC staining of human kidney.
  • IHC - KLK6 / Kallikrein 6 Antibody (aa145-156) ALS16151
    Anti-KLK6 / Kallikrein 6 antibody IHC staining of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q92876
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 27kDa
Dilution ELISA (1:128000), IHC-P (5 µg/ml),
Additional Information
Gene ID 5653
Other Names Kallikrein-6, 3.4.21.-, Neurosin, Protease M, SP59, Serine protease 18, Serine protease 9, Zyme, KLK6, PRSS18, PRSS9
Target/Specificity Human KLK6 / Kallikrein 6. This antibody is expected to recognize both reported isoforms (NP_002765.1; NP_001012983.1). Reported variants represent identical protein: NP_002765.1, NP_001012982.1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsKLK6 / Kallikrein 6 Antibody (aa145-156) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLK6
Synonyms PRSS18, PRSS9
Function Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
Cellular Location Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress
Tissue Location In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions Overexpressed in primary breast tumors but not expressed in metastatic tumors.
Research Areas
Citations (0)

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Background

Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

References

Anisowicz A.,et al.Mol. Med. 2:624-636(1996).
Yamashiro K.,et al.Biochim. Biophys. Acta 1350:11-14(1997).
Little S.P.,et al.J. Biol. Chem. 272:25135-25142(1997).
Yousef G.M.,et al.Genomics 62:251-259(1999).
Gan L.,et al.Gene 257:119-130(2000).

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$ 395.00
Cat# ALS16151
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