|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:10000-1:50000), IHC-P (15 µg/ml), WB (1:1000)|
|Other Names||Mesothelin, CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, Megakaryocyte-potentiating factor, MPF, Mesothelin, cleaved form, MSLN, MPF|
|Target/Specificity||Cross reactivity with homologues from other sources has not been tested.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||MSLN / Mesothelin Antibody (Extracellular Domain, clone MN-1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Membrane-anchored forms may play a role in cellular adhesion.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus Isoform 3: Secreted.|
|Tissue Location||Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Membrane-anchored forms may play a role in cellular adhesion.
Kojima T.,et al.J. Biol. Chem. 270:21984-21990(1995).
Chang K.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:136-140(1996).
Muminova Z.E.,et al.BMC Cancer 4:19-19(2004).
Ho M.,et al.Clin. Cancer Res. 11:3814-3820(2005).
Daniels R.J.,et al.Hum. Mol. Genet. 10:339-352(2001).
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