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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PCSK1N / PROSAAS Antibody (aa182-193)   

PCSK1N / PROSAAS Antibody (aa182-193)

Goat Polyclonal Antibody

     
  • IHC - PCSK1N / PROSAAS Antibody (aa182-193) ALS16157
    Anti-PCSK1N / PROSAAS antibody IHC staining of human pancreas.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q9UHG2
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 27kDa
Dilution ELISA (1:1000), IHC-P (5 µg/ml),
Additional Information
Gene ID 27344
Other Names ProSAAS, Proprotein convertase subtilisin/kexin type 1 inhibitor, Proprotein convertase 1 inhibitor, pro-SAAS, KEP, Big SAAS, b-SAAS, Little SAAS, l-SAAS, N-proSAAS, Big PEN-LEN, b-PEN-LEN, SAAS CT(1-49), PEN, Little LEN, l-LEN, Big LEN, b-LEN, SAAS CT(25-40), PCSK1N
Target/Specificity Human PCSK1N / PROSAAS.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsPCSK1N / PROSAAS Antibody (aa182-193) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCSK1N
Function May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity).
Cellular Location Secreted {ECO:0000250|UniProtKB:Q9QXV0}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9QXV0}. Note=A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Guam disease).
Tissue Location Expressed in brain and pancreas.
Research Areas
Citations (0)

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Background

May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity).

References

Fricker L.,et al.J. Neurosci. 20:639-648(2000).
Basak A.,et al.J. Biol. Chem. 276:32720-32728(2001).
Kikuchi K.,et al.Biochem. Biophys. Res. Commun. 308:646-654(2003).
Wada M.,et al.Neurosci. Lett. 356:49-52(2004).
Nilsson J.,et al.Nat. Methods 6:809-811(2009).

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$ 395.00
Cat# ALS16157
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