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NCOA3 / SRC-3 / AIB1 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - NCOA3 / SRC-3 / AIB1 Antibody (Internal) ALS16164
    Anti-NCOA3 / SRC-3 / AIB1 antibody IHC staining of human skin.
  • IHC - NCOA3 / SRC-3 / AIB1 Antibody (Internal) ALS16164
    Anti-NCOA3 / SRC-3 / AIB1 antibody IHC staining of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9Y6Q9
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 155kDa
Dilution ELISA (1:175000), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 8202
Other Names Nuclear receptor coactivator 3, NCoA-3, 2.3.1.48, ACTR, Amplified in breast cancer 1 protein, AIB-1, CBP-interacting protein, pCIP, Class E basic helix-loop-helix protein 42, bHLHe42, Receptor-associated coactivator 3, RAC-3, Steroid receptor coactivator protein 3, SRC-3, Thyroid hormone receptor activator molecule 1, TRAM-1, NCOA3, AIB1, BHLHE42, RAC3, TRAM1
Target/Specificity This antibody reacts with several isoforms of human NCOA3 protein (a, b, d, e and f). A BLAST analysis was used to suggest cross-reactivity with NCOA3 from human and macaque sources based on a 100% homology with the immunizing sequence. Expect partia ...
Reconstitution & Storage Long term: -20°C; Short term: -20°C
PrecautionsNCOA3 / SRC-3 / AIB1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCOA3
Synonyms AIB1, BHLHE42, RAC3, TRAM1
Function Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
Cellular Location Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus
Tissue Location Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney
Research Areas
Citations (0)

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Background

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

References

Takeshita A.,et al.J. Biol. Chem. 272:27629-27634(1997).
Chen H.,et al.Cell 90:569-580(1997).
Anzick S.L.,et al.Science 277:965-968(1997).
Li H.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:8479-8484(1997).
Deloukas P.,et al.Nature 414:865-871(2001).

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$ 395.00
Cat# ALS16164
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