|Application ||WB, IHC-P, E|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Serine/arginine-rich splicing factor 9, Pre-mRNA-splicing factor SRp30C, Splicing factor, arginine/serine-rich 9, SRSF9, SFRS9, SRP30C|
|Target/Specificity||Human SRSF9 / SFRS9|
|Reconstitution & Storage||Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.|
|Precautions||SRSF9 / SFRS9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.|
|Cellular Location||Nucleus. Note=Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells|
|Tissue Location||Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in the brain, liver, lung and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.
Screaton G.R.,et al.EMBO J. 14:4336-4349(1995).
Yamagata K.,et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).
Yuan Y.,et al.J. Biol. Chem. 273:20347-20353(1998).
Nayler O.,et al.Nucleic Acids Res. 26:3542-3549(1998).
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