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PAX5 Antibody (clone 7D3)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q02548 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 7D3 |
| Calculated MW | 42kDa |
| Dilution | ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500-1:2000) |
| Gene ID | 5079 |
|---|---|
| Other Names | Paired box protein Pax-5, B-cell-specific transcription factor, BSAP, PAX5 |
| Target/Specificity | Human PAX5 |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
| Precautions | PAX5 Antibody (clone 7D3) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PAX5 |
|---|---|
| Function | Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage- specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin- release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238). |
| Cellular Location | Nucleus. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.
References
Adams B.,et al.Genes Dev. 6:1589-1607(1992).
Robichaud G.A.,et al.J. Biol. Chem. 279:49956-49963(2004).
Arseneau J.R.,et al.Br. J. Haematol. 147:328-338(2009).
Livingston R.J.,et al.Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
Humphray S.J.,et al.Nature 429:369-374(2004).
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