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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   MCAM / CD146 Antibody (aa84-189, clone 6C3E6)   

MCAM / CD146 Antibody (aa84-189, clone 6C3E6)

Mouse Monoclonal Antibody

     
  • IHC - MCAM / CD146 Antibody (aa84-189, clone 6C3E6) ALS16191
    Anti-MCAM / CD146 antibody IHC staining of human lung.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, Flo
Primary Accession P43121
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6C3E6
Calculated MW 72kDa
Dilution ELISA (1:10000), Flo (1:200-1:400), IHC-P (10 µg/ml), WB (1:500-1:2000) ,
Additional Information
Gene ID 4162
Other Names Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12, Melanoma cell adhesion molecule, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, S-endo 1 endothelial-associated antigen, CD146, MCAM, MUC18
Target/Specificity Human MCAM / CD146
Reconstitution & Storage Short term +4°C; Long term -20°C
PrecautionsMCAM / CD146 Antibody (aa84-189, clone 6C3E6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCAM
Synonyms MUC18
Function Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis
Research Areas
Citations (0)

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Background

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

References

Lehmann J.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:9891-9895(1989).
Sers C.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:8514-8518(1993).
Solovey A.N.,et al.J. Lab. Clin. Med. 138:322-331(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16191
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