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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KNG1 / Kininogen / Bradykinin Antibody (aa1-416)   

KNG1 / Kininogen / Bradykinin Antibody (aa1-416)

Rabbit Polyclonal Antibody

     
  • WB - KNG1 / Kininogen / Bradykinin Antibody (aa1-416) ALS16192
    Sample (30 ug of whole cell lysate).
  • ICC - KNG1 / Kininogen / Bradykinin Antibody (aa1-416) ALS16192
    Immunofluorescence of paraformaldehyde-fixed HeLa using Kininogen-1 antibody at 1:200 dilution.
  • IHC - KNG1 / Kininogen / Bradykinin Antibody (aa1-416) ALS16192
    Anti-KNG1 / Kininogen / Bradykinin antibody IHC staining of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC
Primary Accession P01042
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 72kDa
Dilution ICC (1:100-1:1000), IHC-P (7.5 µg/ml), WB (1:500-1:3000)
Additional Information
Gene ID 3827
Other Names Kininogen-1, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight kininogen, HMWK, Williams-Fitzgerald-Flaujeac factor, Kininogen-1 heavy chain, T-kinin, Ile-Ser-Bradykinin, Bradykinin, Kallidin I, Lysyl-bradykinin, Kallidin II, Kininogen-1 light chain, Low molecular weight growth-promoting factor, KNG1, BDK, KNG
Target/Specificity Human Kininogen / Bradykinin
Reconstitution & Storage Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsKNG1 / Kininogen / Bradykinin Antibody (aa1-416) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KNG1
Synonyms BDK, KNG
Function (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting.
Cellular Location Secreted, extracellular space.
Tissue Location Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.
Volume 50 µl
Research Areas
Citations (0)

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Background

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting.

References

Ohkubo I.,et al.Biochemistry 23:5691-5697(1984).
Takagaki Y.,et al.J. Biol. Chem. 260:8601-8609(1985).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Muzny D.M.,et al.Nature 440:1194-1198(2006).

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$ 395.00
Cat# ALS16192
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