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RARG / RAR-Gamma Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P13631 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50kDa |
| Dilution | IHC-P (7.5 µg/ml), WB (1:500-1:3000), |
| Gene ID | 5916 |
|---|---|
| Other Names | Retinoic acid receptor gamma, RAR-gamma, Nuclear receptor subfamily 1 group B member 3, RARG, NR1B3 |
| Target/Specificity | Human, mouse RARG |
| Reconstitution & Storage | Aliquot and freeze at -20° C. Avoid freeze-thaw cycles. |
| Precautions | RARG / RAR-Gamma Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RARG |
|---|---|
| Synonyms | NR1B3 |
| Function | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Expressed in aortic endothelial cells (at protein level). |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
References
Krust A.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:5310-5314(1989).
Ishikawa T.,et al.Mol. Endocrinol. 4:837-844(1990).
Lehmann J.M.,et al.Nucleic Acids Res. 19:573-578(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
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