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JAM2 Antibody (aa1-294)

Rabbit Polyclonal Antibody

     
  • WB - JAM2 Antibody (aa1-294) ALS16197
    Sample (30 ug of whole cell lysate).
    detail
  • WB - JAM2 Antibody (aa1-294) ALS16197
    JAM-B antibody detects JAM2 protein by Western blot analysis.
    detail
  • IHC - JAM2 Antibody (aa1-294) ALS16197
    Anti-JAM-B / JAM2 antibody IHC staining of human placenta.
    detail
  • SPECIFICATION
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P57087
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 33kDa
Dilution IHC-P (7.5 µg/ml), WB (1:500-1:3000),
Additional Information
Gene ID 58494
Other Names Junctional adhesion molecule B, JAM-B, Junctional adhesion molecule 2, JAM-2, Vascular endothelial junction-associated molecule, VE-JAM, CD322, JAM2, C21orf43, VEJAM
Target/Specificity Human JAM-B / JAM2
Reconstitution & Storage Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsJAM2 Antibody (aa1-294) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name JAM2 (HGNC:14686)
Function Junctional adhesion protein that mediates heterotypic cell- cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed:11590146, PubMed:11823489, PubMed:24357068). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed:24357068). At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed:12239159). Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed:12070135). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9JI59}. Note=Localized at tight junctions of both epithelial and endothelial cells (By similarity). Specifically localized within the somatodendritic compartment of neurons and excluded from the axon (By similarity) {ECO:0000250|UniProtKB:Q9JI59}
Tissue Location Highly expressed in heart, placenta, lung, foreskin and lymph node (PubMed:10779521, PubMed:10945976). Prominently expressed on high endothelial venules and also present on the endothelia of other vessels (at protein level) (PubMed:10779521, PubMed:10945976). Also expressed in the brain in the caudate nuclei (PubMed:31851307).
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

May play a role in the processes of lymphocyte homing to secondary lymphoid organs.

References

Palmeri D.,et al.J. Biol. Chem. 275:19139-19145(2000).
Cunningham S.A.,et al.J. Biol. Chem. 275:34750-34756(2000).
Gardiner K.,et al.Genomics 79:833-843(2002).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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Discontinued
Cat# ALS16197
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