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ARF1 Antibody (aa50-104)

Rabbit Polyclonal Antibody

     
  • WB - ARF1 Antibody (aa50-104) ALS16199
    Sample (30 ug of whole cell lysate). A: Hep G2. 12% SDS PAGE. ARF1 antibody diluted at 1:500
  • WB - ARF1 Antibody (aa50-104) ALS16199
    ARF1 antibody detects ARF1 protein by Western blot analysis.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P84077
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 21kDa
Dilution IHC-P (7.5 µg/ml), WB (1:500-1:3000),
Additional Information
Gene ID 375
Other Names ADP-ribosylation factor 1, ARF1
Target/Specificity Human ARF1
Reconstitution & Storage Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsARF1 Antibody (aa50-104) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARF1
Function GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
Cellular Location Golgi apparatus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Membrane; Lipid- anchor
Volume 50 µl
Research Areas
Citations (0)

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Background

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

References

Bobak D.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:6101-6105(1989).
Kahn R.A.,et al.J. Biol. Chem. 266:2606-2614(1991).
Lee C.M.,et al.J. Biol. Chem. 267:9028-9034(1992).
Yu W.,et al.Genome Res. 7:353-358(1997).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16199
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