|Application ||WB, IHC-P|
|Dilution||IHC-P (7.5 µg/ml), WB (1:500-1:3000),|
|Other Names||AarF domain-containing protein kinase 4, 2.7.11.-, ADCK4|
|Reconstitution & Storage||Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.|
|Precautions||ADCK4 Antibody (aa141-460) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:24270420). Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration (PubMed:24270420).|
|Cellular Location||Mitochondrion membrane; Single-pass membrane protein. Cytoplasm, cytosol. Cell membrane|
|Tissue Location||Widely expressed, including renal podocytes.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
May play a role in CoQ10 (COQ10A and/or COQ10B) biosynthesis, which is required for podocyte migration.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Greenman C.,et al.Nature 446:153-158(2007).
Ashraf S.,et al.J. Clin. Invest. 123:5179-5189(2013).
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