|Application ||WB, IHC-P, ICC|
|Dilution||ICC (1:100-1:1000), IHC-P (7.5 µg/ml), WB (1:500-1:3000)|
|Other Names||Aldo-keto reductase family 1 member C1, 1.1.1.-, 20-alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, 18.104.22.168, Chlordecone reductase homolog HAKRC, Dihydrodiol dehydrogenase 1/2, DD1/DD2, High-affinity hepatic bile acid-binding protein, HBAB, Indanol dehydrogenase, 22.214.171.124, Trans-1, 2-dihydrobenzene-1, 2-diol dehydrogenase, 126.96.36.199, AKR1C1, DDH, DDH1|
|Target/Specificity||Human DDH / AKR1C1|
|Reconstitution & Storage||Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.|
|Precautions||DDH / AKR1C1 Antibody (aa22-248) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.|
|Tissue Location||Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.|
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Provided below are standard protocols that you may find useful for product applications.
Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
Stolz A.,et al.J. Biol. Chem. 268:10448-10457(1993).
Lou H.,et al.J. Biol. Chem. 269:8416-8422(1994).
Ciaccio P.J.,et al.J. Biol. Chem. 269:15558-15562(1994).
Khanna M.,et al.J. Steroid Biochem. Mol. Biol. 53:41-46(1995).
Nishizawa M.,et al.Genes Cells 5:111-125(2000).
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