|Application ||WB, IHC-P, ICC|
|Dilution||ICC (1:100-1:1000), IHC-P (7.5 µg/ml), WB (1:500-1:3000)|
|Other Names||Lactoylglutathione lyase, 220.127.116.11, Aldoketomutase, Glyoxalase I, Glx I, Ketone-aldehyde mutase, Methylglyoxalase, S-D-lactoylglutathione methylglyoxal lyase, GLO1|
|Target/Specificity||Human GLO1 / Glyoxalase I|
|Reconstitution & Storage||Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.|
|Precautions||GLO1 / Glyoxalase I Antibody (aa1-184) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis.|
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Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis.
Kim N.-S.,et al.J. Biol. Chem. 268:11217-11221(1993).
Ranganathan S.,et al.J. Biol. Chem. 268:5661-5667(1993).
Ridderstroem M.,et al.Biochem. J. 314:463-467(1996).
Ranganathan S.,et al.Gene 240:149-155(1999).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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