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DKK3 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - DKK3 Antibody ALS16222
    Anti-DKK3 antibody IHC staining of human kidney.
  • WB - DKK3 Antibody ALS16222
    Sample (30 ug of whole cell lysate) A: 293T 10% SDS PAGE DKK3 antibody diluted at 1:1000
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9UBP4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 38kDa
Dilution IHC-P (7.5 µg/ml), WB (1:500-1:3000),
Additional Information
Gene ID 27122
Other Names Dickkopf-related protein 3, Dickkopf-3, Dkk-3, hDkk-3, DKK3, REIC
Target/Specificity Human DKK3
Reconstitution & Storage Aliquot and freeze at -20° C. Avoid freeze-thaw cycles.
PrecautionsDKK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DKK3
Synonyms REIC
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Cellular Location Secreted.
Tissue Location Highest expression in heart, brain, and spinal cord. {ECO:0000269|PubMed:10570958, ECO:0000269|Ref.4}
Volume 50 µl
Research Areas
Citations (0)

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Background

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

References

Krupnik V.E.,et al.Gene 238:301-313(1999).
Tsuji T.,et al.Biochem. Biophys. Res. Commun. 268:20-24(2000).
Kobayashi K.,et al.Gene 282:151-158(2002).
Tanaka S.,et al.Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
Tate G.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16222
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