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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AZIN2 / Antizyme Inhibitor 2 Antibody (Internal)   

AZIN2 / Antizyme Inhibitor 2 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - AZIN2 / Antizyme Inhibitor 2 Antibody (Internal) ALS16225
    Anti-Arginine Decarboxylase / ADC antibody IHC staining of human liver.
  • IHC - AZIN2 / Antizyme Inhibitor 2 Antibody (Internal) ALS16225
    Anti-Arginine Decarboxylase / ADC antibody IHC staining of human small intestine.
  • WB - AZIN2 / Antizyme Inhibitor 2 Antibody (Internal) ALS16225
    Sample (30 ug of whole cell lysate) A: SK-N-SH 10% SDS PAGE ADC antibody diluted at 1:5000
  • WB - AZIN2 / Antizyme Inhibitor 2 Antibody (Internal) ALS16225
    Sample (30 ug) A: Human normal cerebellar extract 10% SDS PAGE ADC antibody diluted at 1:1500
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q96A70
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 50kDa
Dilution IHC-P (7.5 µg/ml), WB (1:1000-1:10000),
Additional Information
Gene ID 113451
Other Names Antizyme inhibitor 2, AzI2, Arginine decarboxylase, ADC, ARGDC, Ornithine decarboxylase-like protein, ODC-like protein, ornithine decarboxylase paralog, ODC-p, AZIN2, ADC, KIAA1945, ODCP
Target/Specificity Human ADC
Reconstitution & Storage Aliquot and freeze at -20° C. Avoid freeze-thaw cycles.
PrecautionsAZIN2 / Antizyme Inhibitor 2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AZIN2
Synonyms ADC, KIAA1945, ODCP
Function Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizymes OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC1 degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).
Cellular Location Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Membrane. Cytoplasmic vesicle Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network Golgi apparatus, trans-Golgi network. Cytoplasmic granule. Cell projection, axon. Cell projection, dendrite. Perikaryon Note=Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in a antizyme-dependent manner. Localizes with vesicle- associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules (By similarity). Detected as vesicle-like pattern in neurite outgrowths. Localizes to the vesicular compartments of the secretory pathway, predominantly in the trans-Golgi network (TGN) Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules.
Tissue Location Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis.
Volume 50 µl
Research Areas
Citations (0)

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Background

Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizymes OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC1 degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).

References

Pitkaenen L.T.,et al.Biochem. Biophys. Res. Commun. 287:1051-1057(2001).
Zhu M.-Y.,et al.Biochim. Biophys. Acta 1670:156-164(2004).
Nagase T.,et al.DNA Res. 8:319-327(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 395.00
Cat# ALS16225
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(40 western blots)
Availability: 5 days
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