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TIP30 / HTATIP2 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC, IP |
|---|---|
| Primary Accession | Q9BUP3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 27kDa |
| Dilution | ICC (1:100-1:1000), IF (1:100-1:1000), IHC-P (5 µg/ml), IP (1:100-1:500), WB (1:1000-1:10000) |
| Gene ID | 10553 |
|---|---|
| Other Names | Oxidoreductase HTATIP2, 1.1.1.-, 30 kDa HIV-1 TAT-interacting protein, HIV-1 TAT-interactive protein 2, HTATIP2 (HGNC:16637) |
| Target/Specificity | Human HTATIP2 / TIP30 |
| Reconstitution & Storage | Aliquot and freeze at -20° C. Avoid freeze-thaw cycles. |
| Precautions | TIP30 / HTATIP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HTATIP2 (HGNC:16637) |
|---|---|
| Function | Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. |
| Cellular Location | Cytoplasm. Nucleus envelope |
| Tissue Location | Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
References
Shtivelman E.,et al.Oncogene 14:2167-2173(1997).
Xiao H.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:2146-2151(1998).
Whitman S.,et al.Mol. Cell. Biol. 20:583-593(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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