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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TIP30 / HTATIP2 Antibody   

TIP30 / HTATIP2 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - TIP30 / HTATIP2 Antibody ALS16229
    Anti-TIP30 / HTATIP2 antibody IHC staining of human small intestine.
  • WB - TIP30 / HTATIP2 Antibody ALS16229
    Sample (30 ug of whole cell lysate) A: A431 B: HeLa 12% SDS PAGE HTATIP2 / TIP30 antibody...
  • IF - TIP30 / HTATIP2 Antibody ALS16229
    Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using TIP30...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, IP
Primary Accession Q9BUP3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 27kDa
Dilution ICC (1:100-1:1000), IF (1:100-1:1000), IHC-P (5 µg/ml), IP (1:100-1:500), WB (1:1000-1:10000)
Additional Information
Gene ID 10553
Other Names Oxidoreductase HTATIP2, 1.1.1.-, 30 kDa HIV-1 TAT-interacting protein, HIV-1 TAT-interactive protein 2, HTATIP2 (HGNC:16637)
Target/Specificity Human HTATIP2 / TIP30
Reconstitution & Storage Aliquot and freeze at -20° C. Avoid freeze-thaw cycles.
PrecautionsTIP30 / HTATIP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTATIP2 (HGNC:16637)
Function Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
Cellular Location Cytoplasm. Nucleus envelope
Tissue Location Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas
Volume 50 µl
Research Areas
Citations (0)

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Background

Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

References

Shtivelman E.,et al.Oncogene 14:2167-2173(1997).
Xiao H.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:2146-2151(1998).
Whitman S.,et al.Mol. Cell. Biol. 20:583-593(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16229
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