|Application ||WB, IHC-P, IF|
|Dilution||IF (1:100), IHC-P (15 µg/ml), WB (1:200-1:2000)|
|Other Names||Dixin, Coiled-coil protein DIX1, Coiled-coil-DIX1, DIX domain-containing protein 1, DIXDC1, CCD1, KIAA1735|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||DIXDC1 Antibody (clone 6B6) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.|
|Cellular Location||Cytoplasm, cytosol. Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis Isoform 2: Cytoplasm.|
|Tissue Location||Ubiquitously expressed with higher expression in cardiac and skeletal muscles.|
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Provided below are standard protocols that you may find useful for product applications.
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.
Wang X.,et al.Biochem. Biophys. Res. Commun. 347:22-30(2006).
Nagase T.,et al.DNA Res. 7:347-355(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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