|Application ||WB, IHC-P, IF|
|Dilution||IF (1:50-1:200), IHC-P (1:100), WB (1:500-1:1000)|
|Other Names||Transmembrane protease serine 3, 3.4.21.-, Serine protease TADG-12, Tumor-associated differentially-expressed gene 12 protein, TMPRSS3, ECHOS1, TADG12|
|Reconstitution & Storage||Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.|
|Precautions||TMPRSS3 Antibody (aa420-460) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas|
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Provided below are standard protocols that you may find useful for product applications.
Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro).
Underwood L.J.,et al.Biochim. Biophys. Acta 1502:337-350(2000).
Scott H.S.,et al.Nat. Genet. 27:59-63(2001).
Ahmed Z.M.,et al.BMC Med. Genet. 5:24-24(2004).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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