|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Other Names||Cystinosin, CTNS|
|Target/Specificity||Human CTNS / Cystinosin|
|Reconstitution & Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CTNS / Cystinosin Antibody (clone 5G6) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR.|
|Cellular Location||Isoform 1: Lysosome membrane; Multi-pass membrane protein. Melanosome|
|Tissue Location||Strongly expressed in pancreas, kidney (adult and fetal), skeletal muscle, melanocytes and keratinocytes Expressed at lower levels in placenta and heart. Weakly expressed in lung, liver and brain (adult and fetal). Isoform 2 represents 5-20 % of CTNS transcripts, with the exception of the testis that expresses both isoforms in equal proportions|
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Provided below are standard protocols that you may find useful for product applications.
Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR.
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Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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