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AHI1 Antibody (aa1-42)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q8N157 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 137kDa |
| Dilution | IHC-P (5 µg/ml), WB (1:500-1:3000), |
| Gene ID | 54806 |
|---|---|
| Other Names | Jouberin, Abelson helper integration site 1 protein homolog, AHI-1, AHI1 |
| Target/Specificity | Human AHI1 |
| Reconstitution & Storage | Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
| Precautions | AHI1 Antibody (aa1-42) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AHI1 |
|---|---|
| Function | Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). |
| Cellular Location | Cytoplasm, cytoskeleton, cilium basal body. Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8K3E5}. Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium {ECO:0000250|UniProtKB:Q8K3E5} |
| Tissue Location | Highly expressed in the most primitive normal hematopoietic cells. Expressed in brain, particularly in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles. Expressed in kidney (renal collecting duct cells) (at protein level). |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.
References
Close J.P.,et al.BMC Genomics 5:33-33(2004).
Westin E.H.,et al.Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
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