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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   AIF1 / IBA1 Antibody (aa85-147)   

AIF1 / IBA1 Antibody (aa85-147)

Rabbit Polyclonal Antibody

     
  • WB - AIF1 / IBA1 Antibody (aa85-147) ALS16267
    Sample (30 ug of whole cell lysate).
  • IHC - AIF1 / IBA1 Antibody (aa85-147) ALS16267
    Anti-AIF1 / IBA1 antibody IHC staining of human kidney.
  • WB - AIF1 / IBA1 Antibody (aa85-147) ALS16267
    A: 30 µg THP-1 whole cell lysate/extract.
  • WB - AIF1 / IBA1 Antibody (aa85-147) ALS16267
    A: 50 µg mouse brain lysate/extract. 15 % SDS-PAGE. AIF1 / IBA1 antibody diluted at 1:1000.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P55008
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 17kDa
Dilution IHC-P (1:100), WB (1:500-1:3000),
Additional Information
Gene ID 199
Other Names Allograft inflammatory factor 1, AIF-1, Ionized calcium-binding adapter molecule 1, Protein G1, AIF1, G1, IBA1
Target/Specificity Human AIF1 / IBA1
Reconstitution & Storage Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsAIF1 / IBA1 Antibody (aa85-147) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AIF1
Synonyms G1, IBA1
Function Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Cellular Location Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O70200}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O70200}; Peripheral membrane protein {ECO:0000250|UniProtKB:O70200}; Cytoplasmic side {ECO:0000250|UniProtKB:O70200}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:O70200}. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis {ECO:0000250|UniProtKB:O70200}
Tissue Location Detected in T-lymphocytes and peripheral blood mononuclear cells.
Volume 50 µl
Research Areas
Citations (0)

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Background

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

References

Albertella M.R.,et al.Hum. Mol. Genet. 3:793-799(1994).
Holzinger I.,et al.Immunogenetics 42:315-322(1995).
Autieri M.V.,et al.Biochem. Biophys. Res. Commun. 228:29-37(1996).
Utans U.,et al.Transplantation 61:1387-1392(1996).
de Baey A.,et al.Genomics 45:591-600(1997).

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$ 395.00
Cat# ALS16267
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