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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   TFB2M Antibody (C-Terminus)   

TFB2M Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - TFB2M Antibody (C-Terminus) ALS16275
    Anti-TFB2M antibody IHC staining of human colon.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q9H5Q4
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 45kDa
Dilution ELISA (1:128000), IHC-P (5 µg/ml),
Additional Information
Gene ID 64216
Other Names Dimethyladenosine transferase 2, mitochondrial, 2.1.1.-, Hepatitis C virus NS5A-transactivated protein 5, HCV NS5A-transactivated protein 5, Mitochondrial 12S rRNA dimethylase 2, Mitochondrial transcription factor B2, h-mtTFB, h-mtTFB2, hTFB2M, mtTFB2, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2, TFB2M, NS5ATP5
Target/Specificity Human TFB2M.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsTFB2M Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TFB2M
Synonyms NS5ATP5
Function S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.
Cellular Location Mitochondrion.
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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Background

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.

References

Liu Y.,et al.Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Falkenberg M.,et al.Nat. Genet. 31:289-294(2002).
McCulloch V.,et al.Mol. Cell. Biol. 23:5816-5824(2003).

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$ 395.00
Cat# ALS16275
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