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>   home   >   Products   >   Primary Antibodies   >   FAM175A / CCDC98 Antibody (aa350-400)   

FAM175A / CCDC98 Antibody (aa350-400)

Rabbit Polyclonal Antibody

     
  • IHC - FAM175A / CCDC98 Antibody (aa350-400) ALS16279
    Anti-FAM175A / CCDC98 antibody IHC staining of human testis.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession Q6UWZ7
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 47kDa
Dilution IHC-P (1:100), IP (5-15 µg/mg lysate), WB (1:2000-1:10000)
Additional Information
Gene ID 84142
Other Names BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98, Protein FAM175A, FAM175A, ABRA1, CCDC98
Target/Specificity Region between residue 350 and 400 of human Abraxas (coiled-coil domain containing 98) using the numbering given in entry NP_620775.2 (GeneID 84142).
Reconstitution & Storage Store at 2-8°C for up to 1 year.
PrecautionsFAM175A / CCDC98 Antibody (aa350-400) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FAM175A
Synonyms ABRA1, CCDC98
Function Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Cellular Location Nucleus Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Volume 50 µl
Citations (0)

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Background

Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.

References

Wang B.,et al.Science 316:1194-1198(2007).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Liu Z.,et al.Nat. Struct. Mol. Biol. 14:716-720(2007).

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Discontinued
Cat# ALS16279
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