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HRH3 / Histamine 3 Receptor Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - HRH3 / Histamine 3 Receptor Antibody (Internal) ALS16292
    HRH3 antibody (0.1 ug/ml) staining of A549 lysate (35 ug protein in RIPA buffer).
    detail
  • IHC - HRH3 / Histamine 3 Receptor Antibody (Internal) ALS16292
    Anti-HRH3 / Histamine 3 Receptor antibody IHC staining of human prostate.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9Y5N1
Reactivity Human, Hamster, Horse, Bovine, Guinea Pig, Dog
Host Goat
Clonality Polyclonal
Calculated MW 49kDa
Dilution ELISA (1:128000), IHC-P (5 µg/ml), WB (0.1-0.3 µg/ml)
Additional Information
Gene ID 11255
Other Names Histamine H3 receptor, H3R, HH3R, G-protein coupled receptor 97, HRH3, GPCR97
Target/Specificity Human HRH3 / Histamine 3 Receptor
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsHRH3 / Histamine 3 Receptor Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HRH3
Synonyms GPCR97
Function The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra
Research Areas
Citations (0)
citation

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Background

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.

References

Lovenberg T.W.,et al.Mol. Pharmacol. 55:1101-1107(1999).
Nakamura T.,et al.Biochem. Biophys. Res. Commun. 279:615-620(2000).
Coge F.,et al.Biochem. J. 355:279-288(2001).
Wiedemann P.,et al.J. Neural Transm. 109:443-453(2002).
Ullmer C.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS16292
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