|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml)|
|Other Names||Calpain-1 catalytic subunit, 184.108.40.206, Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Cell proliferation-inducing gene 30 protein, Micromolar-calpain, muCANP, CAPN1, CANPL1|
|Target/Specificity||Human CAPN1 / Calpain 1. Reported variants represent identical protein: NP_001185797.1, NP_005177.2, NP_001185798.1.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CAPN1 / Calpain 1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.|
|Cellular Location||Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding|
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Provided below are standard protocols that you may find useful for product applications.
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Aoki K.,et al.FEBS Lett. 205:313-317(1986).
Sorimachi H.,et al.Biol. Chem. Hoppe-Seyler 371:171-176(1990).
Kim J.W.,et al.Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
Melloni E.,et al.Biochem. Biophys. Res. Commun. 229:193-197(1996).
Michetti M.,et al.FEBS Lett. 392:11-15(1996).
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