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INPP5A Antibody (aa128-330)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q14642 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 48kDa |
| Dilution | ELISA (1:20000-1:80000), IHC-P (5 µg/ml), WB (1:500-1:1000) |
| Gene ID | 3632 |
|---|---|
| Other Names | Type I inositol 1, 4, 5-trisphosphate 5-phosphatase, 5PTase, 3.1.3.56, INPP5A |
| Target/Specificity | Human INPP5A. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | INPP5A Antibody (aa128-330) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | INPP5A (HGNC:6076) |
|---|---|
| Function | Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8013665, PubMed:8769125, PubMed:8626616). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor {ECO:0000269|PubMed:8626616, ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7TNC9} |
| Tissue Location | Predominantly expressed in heart, brain, and skeletal muscle (PubMed:8006039). In brain; high level in Purkinje cells (PubMed:8013665). |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.
References
de Smedt F.,et al.FEBS Lett. 347:69-72(1994).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Laxminarayan K.M.,et al.J. Biol. Chem. 269:17305-17310(1994).
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