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DVL1 / DVL / Dishevelled Antibody (aa20-32)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O14640 |
| Reactivity | Human, Mouse, Rat, Monkey, Pig, Sheep, Bovine, Guinea Pig |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 75kDa |
| Dilution | ELISA (1:128000), IHC-P (5 µg/ml), WB (1-3 µg/ml) |
| Gene ID | 1855 |
|---|---|
| Other Names | Segment polarity protein dishevelled homolog DVL-1, Dishevelled-1, DSH homolog 1, DVL1 |
| Target/Specificity | Human DVL1 / DVL / Dishevelled. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | DVL1 / DVL / Dishevelled Antibody (aa20-32) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DVL1 |
|---|---|
| Function | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| Cellular Location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasmic vesicle Note=Localizes at the cell membrane upon interaction with frizzled family members. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
References
Semenov M.V.,et al.Genomics 42:302-310(1997).
Gregory S.G.,et al.Nature 441:315-321(2006).
Chen W.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:14889-14894(2001).
Oshita A.,et al.Genes Cells 8:1005-1017(2003).
Lu W.,et al.Cell 119:97-108(2004).
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