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DVL1 / DVL / Dishevelled Antibody (aa20-32)

Goat Polyclonal Antibody

     
  • IHC - DVL1 / DVL / Dishevelled Antibody (aa20-32) ALS16309
    Anti-DVL1 / DVL / Dishevelled antibody IHC staining of human kidney.
  • IHC - DVL1 / DVL / Dishevelled Antibody (aa20-32) ALS16309
    Anti-DVL1 / DVL / Dishevelled antibody IHC staining of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O14640
Reactivity Human, Mouse, Rat, Monkey, Pig, Sheep, Bovine, Guinea Pig
Host Goat
Clonality Polyclonal
Calculated MW 75kDa
Dilution ELISA (1:128000), IHC-P (5 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 1855
Other Names Segment polarity protein dishevelled homolog DVL-1, Dishevelled-1, DSH homolog 1, DVL1
Target/Specificity Human DVL1 / DVL / Dishevelled.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsDVL1 / DVL / Dishevelled Antibody (aa20-32) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DVL1
Function Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
Cellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytosol. Cytoplasmic vesicle. Note=Localizes at the cell membrane upon interaction with frizzled family members.
Research Areas
Citations (0)

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Background

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).

References

Semenov M.V.,et al.Genomics 42:302-310(1997).
Gregory S.G.,et al.Nature 441:315-321(2006).
Chen W.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:14889-14894(2001).
Oshita A.,et al.Genes Cells 8:1005-1017(2003).
Lu W.,et al.Cell 119:97-108(2004).

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$ 395.00
Cat# ALS16309
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