OAS2 Antibody (aa357-371)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P29728 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 82kDa |
Dilution | ELISA (1:128000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml) |
Gene ID | 4939 |
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Other Names | 2'-5'-oligoadenylate synthase 2, (2-5')oligo(A) synthase 2, 2-5A synthase 2, 2.7.7.84, p69 OAS / p71 OAS, p69OAS / p71OAS, OAS2 |
Target/Specificity | Human OAS2. This antibody is expected to recognize reported isoform 1 (NP_058197.2) and isoform 2 (NP_002526.2). |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | OAS2 Antibody (aa357-371) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | OAS2 (HGNC:8087) |
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Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:9880569, PubMed:11682059). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity). |
Cellular Location | Cytoplasm. Cytoplasm, perinuclear region |
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Background
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
References
Marie I.,et al.J. Biol. Chem. 267:9933-9939(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Sarkar S.N.,et al.J. Biol. Chem. 277:24321-24330(2002).
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