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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   OAS2 Antibody (aa357-371)   

OAS2 Antibody (aa357-371)

Goat Polyclonal Antibody

     
  • WB - OAS2 Antibody (aa357-371) ALS16310
    OAS2 antibody (0.3 ug/ml) staining of Daudi (A), Jurkat (B) and K562 (C) lysates (35 ug protein...
  • IHC - OAS2 Antibody (aa357-371) ALS16310
    Anti-OAS2 antibody IHC staining of human breast.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P29728
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 82kDa
Dilution ELISA (1:128000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 4939
Other Names 2'-5'-oligoadenylate synthase 2, (2-5')oligo(A) synthase 2, 2-5A synthase 2, 2.7.7.84, p69 OAS / p71 OAS, p69OAS / p71OAS, OAS2
Target/Specificity Human OAS2. This antibody is expected to recognize reported isoform 1 (NP_058197.2) and isoform 2 (NP_002526.2).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsOAS2 Antibody (aa357-371) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OAS2
Function Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
Cellular Location Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions
Research Areas
Citations (0)

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Background

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.

References

Marie I.,et al.J. Biol. Chem. 267:9933-9939(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Sarkar S.N.,et al.J. Biol. Chem. 277:24321-24330(2002).

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$ 395.00
Cat# ALS16310
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