|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Pig, Horse, Guinea Pig|
|Dilution||ELISA (1:128000), IHC-P (5 µg/ml), WB (0.1-0.3 µg/ml)|
|Other Names||Macrophage-capping protein, Actin regulatory protein CAP-G, CAPG, AFCP, MCP|
|Target/Specificity||Human CAPG / MCP. This antibody is expected to recognize isoform 1 (NP_001738.2) only. Reported variants represent identical protein: NP_001243068.1, NP_001738.2.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CAPG Antibody (aa205-217) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.|
|Cellular Location||Cytoplasm. Nucleus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Macrophages and macrophage-like cells.|
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Provided below are standard protocols that you may find useful for product applications.
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
Dabiri G.A.,et al.J. Biol. Chem. 267:16545-16552(1992).
Suzuki Y.,et al.Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Mishra V.S.,et al.Genomics 23:560-565(1994).
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