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CAPG Antibody (aa205-217)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P40121 |
| Reactivity | Human, Mouse, Rat, Rabbit, Monkey, Pig, Horse, Guinea Pig |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 38kDa |
| Dilution | ELISA (1:128000), IHC-P (5 µg/ml), WB (0.1-0.3 µg/ml) |
| Gene ID | 822 |
|---|---|
| Other Names | Macrophage-capping protein, Actin regulatory protein CAP-G, CAPG, AFCP, MCP |
| Target/Specificity | Human CAPG / MCP. This antibody is expected to recognize isoform 1 (NP_001738.2) only. Reported variants represent identical protein: NP_001243068.1, NP_001738.2. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | CAPG Antibody (aa205-217) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CAPG |
|---|---|
| Synonyms | AFCP, MCP |
| Function | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
| Cellular Location | Nucleus. Cytoplasm Melanosome. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P24452}. Cell projection, ruffle {ECO:0000250|UniProtKB:P24452}. Note=In macrophages, may be predominantly cytoplasmic. Nuclear localization was observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated in the ruffles of the leading lamellipodia. {ECO:0000250|UniProtKB:P24452} |
| Tissue Location | Macrophages and macrophage-like cells. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
References
Dabiri G.A.,et al.J. Biol. Chem. 267:16545-16552(1992).
Suzuki Y.,et al.Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Mishra V.S.,et al.Genomics 23:560-565(1994).
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