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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   RAD17 Antibody (aa325-375)   

RAD17 Antibody (aa325-375)

Goat Polyclonal Antibody

     
  • WB - RAD17 Antibody (aa325-375) ALS16317
    Detection of Human Rad17 by Western Blot.
  • IHC - RAD17 Antibody (aa325-375) ALS16317
    Anti-RAD17 antibody IHC staining of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, PLA
Primary Accession O75943
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 77kDa
Dilution IHC-P (5 µg/ml), PLA (1:1000-1:10000), WB (1:2500-1:15000)
Additional Information
Gene ID 5884
Other Names Cell cycle checkpoint protein RAD17, hRad17, RF-C/activator 1 homolog, RAD17, R24L
Target/Specificity Region between residues 325 and 375 of human Rad17 using the numbering given in entry NP_002864.1 (GeneID 5884).
Reconstitution & Storage Store at 2-8°C for up to 1 year.
PrecautionsRAD17 Antibody (aa325-375) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAD17
Synonyms R24L
Function Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
Cellular Location Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage
Tissue Location Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors).
Volume 50 µl
Research Areas
Citations (0)

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Background

Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.

References

Dean F.B.,et al.Genomics 54:424-436(1998).
Parker A.E.,et al.J. Biol. Chem. 273:18340-18346(1998).
Parker A.E.,et al.J. Biol. Chem. 274:24438-24438(1999).
Bao S.,et al.Cancer Res. 59:2023-2028(1999).
Bluyssen H.A.R.,et al.Genomics 55:219-228(1999).

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Discontinued
Cat# ALS16317
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