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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   QKI Antibody (C-Terminus)   

QKI Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - QKI Antibody (C-Terminus) ALS16319
    Detection of Human and Mouse QKI by Western Blot.
  • IHC - QKI Antibody (C-Terminus) ALS16319
    Anti-QKI antibody IHC staining of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, IP
Primary Accession Q96PU8
Reactivity Human, Mouse, Rat, Zebrafish, Pig, Chicken, Xenopus, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 38kDa
Dilution IF (1:250-1:1000), IHC-P (1:500-1:2000), IP (2-10 µg/mg lysate), WB (1:5000-1:25000) ,
Additional Information
Gene ID 9444
Other Names Protein quaking, Hqk, HqkI, QKI, HKQ
Target/Specificity The epitope recognized maps to the C-terminus of isoform 5 of human quaking homolog according to entry AAH19917.1 (GeneID 9444). The epitope is not found in isoforms 1, 2, 3, 4, 6, 7 or 7B according to TrEMBL entries Q9P0Y1, Q9P0Y0, Q9P0X6, Q9P0X8, Q ...
Reconstitution & Storage Store at 2-8°C for up to 1 year.
PrecautionsQKI Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name QKI
Synonyms HKQ
Function RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)- UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
Cellular Location Nucleus. Cytoplasm
Tissue Location Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients
Volume 50 µl
Research Areas
Citations (0)

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Background

RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).

References

Li Z.Z.,et al.Jpn. J. Cancer Res. 93:167-177(2002).
Xia J.-H.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
Li H.,et al.Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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Discontinued
Cat# ALS16319
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