|Application ||WB, IHC-P, IF, IP|
|Reactivity||Human, Mouse, Rat, Zebrafish, Pig, Chicken, Xenopus, Bovine, Dog|
|Dilution||IF (1:250-1:1000), IHC-P (1:500-1:2000), IP (2-10 µg/mg lysate), WB (1:5000-1:25000) ,|
|Other Names||Protein quaking, Hqk, HqkI, QKI, HKQ|
|Target/Specificity||The epitope recognized maps to the C-terminus of isoform 5 of human quaking homolog according to entry AAH19917.1 (GeneID 9444). The epitope is not found in isoforms 1, 2, 3, 4, 6, 7 or 7B according to TrEMBL entries Q9P0Y1, Q9P0Y0, Q9P0X6, Q9P0X8, Q ...|
|Reconstitution & Storage||Store at 2-8°C for up to 1 year.|
|Precautions||QKI Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)- UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients|
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RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
Li Z.Z.,et al.Jpn. J. Cancer Res. 93:167-177(2002).
Xia J.-H.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
Li H.,et al.Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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