|Application ||WB, IHC-P, IF|
|Reactivity||Human, Mouse, Rat, Pig, Guinea Pig, Dog|
|Dilution||IF (1:500-1:2500), IHC-P (5 µg/ml), WB (1:1000-1:10000)|
|Other Names||C-Jun-amino-terminal kinase-interacting protein 4, JIP-4, JNK-interacting protein 4, Cancer/testis antigen 89, CT89, Human lung cancer oncogene 6 protein, HLC-6, JNK-associated leucine-zipper protein, JLP, Mitogen-activated protein kinase 8-interacting protein 4, Proliferation-inducing protein 6, Protein highly expressed in testis, PHET, Sperm surface protein, Sperm-associated antigen 9, Sperm-specific protein, Sunday driver 1, SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1|
|Target/Specificity||Region between residue 1 and 50 of human JNK/SAPKAssociated Protein using the numbering given in entry NP_003962.3 (GeneID 9043).|
|Reconstitution & Storage||Store at 2-8°C for up to 1 year.|
|Precautions||SPAG9 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HSS, KIAA0516, MAPK8IP4, SYD1|
|Function||The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Note=Perinuclear distribution in response to stress signals such as UV radiation|
|Tissue Location||Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients.|
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Provided below are standard protocols that you may find useful for product applications.
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction.
Lee C.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:14189-14194(2002).
Guinn B.-A.,et al.Biochem. Biophys. Res. Commun. 335:1293-1304(2005).
Nagase T.,et al.DNA Res. 5:31-39(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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