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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PPP1R10 / PNUTS Antibody (aa350-400)   

PPP1R10 / PNUTS Antibody (aa350-400)

Rabbit Polyclonal Antibody

     
  • WB - PPP1R10 / PNUTS Antibody (aa350-400) ALS16324
    Detection of Human PNUTS by Western Blot.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, IP
Primary Accession Q96QC0
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 99kDa
Dilution IF (1:250-1:1000), IHC-P (5 µg/ml), IP (1-10 µg/mg lysate), WB (1:1000-1:10000) ,
Additional Information
Gene ID 5514
Other Names Serine/threonine-protein phosphatase 1 regulatory subunit 10, MHC class I region proline-rich protein CAT53, PP1-binding protein of 114 kDa, Phosphatase 1 nuclear targeting subunit, Protein FB19, p99, PPP1R10, CAT53, FB19, PNUTS
Target/Specificity Region between residues 350 and 400 of human Phosphatase Nuclear Targeting Subunit (a. k. a. Protein Phosphatase 1, regulatory subunit 10) using the numbering given in TrEMBL entry Q96QC0 (GeneID 5514).
Reconstitution & Storage Store at 2-8°C for up to 1 year.
PrecautionsPPP1R10 / PNUTS Antibody (aa350-400) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP1R10
Synonyms CAT53, FB19, PNUTS
Function Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00649, ECO:0000269|PubMed:9450550}. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity).
Tissue Location Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
Volume 50 µl
Research Areas
Citations (0)

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Background

Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).

References

Totaro A.,et al.Biochem. Biophys. Res. Commun. 250:555-557(1998).
Raha-Chowdhury R.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Shiina S.,et al.Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
Shiina T.,et al.Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).

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Discontinued
Cat# ALS16324
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