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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KIF2C / MCAK Antibody (aa50-100)   

KIF2C / MCAK Antibody (aa50-100)

Rabbit Polyclonal Antibody

     
  • IHC - KIF2C / MCAK Antibody (aa50-100) ALS16327
    Anti-KIF2C / MCAK antibody IHC staining of human testis.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, IP
Primary Accession Q99661
Reactivity Human, Rabbit, Horse
Host Rabbit
Clonality Polyclonal
Calculated MW 81kDa
Dilution IF (1:250-1:1000), IHC-P (5 µg/ml), IP (2-5 µg/mg lysate)
Additional Information
Gene ID 11004
Other Names Kinesin-like protein KIF2C, Kinesin-like protein 6, Mitotic centromere-associated kinesin, MCAK, KIF2C, KNSL6
Target/Specificity Region between residue 50 and 100 of human Mitotic Centromere-Associated Kinesin using the numbering given in entry NP_006836.1 (GeneID 11004).
Reconstitution & Storage Store at 2-8°C for up to 1 year.
PrecautionsKIF2C / MCAK Antibody (aa50-100) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KIF2C
Synonyms KNSL6
Function In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome- microtubule attachment (PubMed:23891108).
Cellular Location Cytoplasm, cytoskeleton. Nucleus {ECO:0000250|UniProtKB:P70096}. Chromosome, centromere Chromosome, centromere, kinetochore Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B Centromeric localization requires the presence of BUB1 and SGO2 {ECO:0000250|UniProtKB:P70096, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:21820309}
Tissue Location Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.
Volume 50 µl
Research Areas
Citations (0)

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Background

In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.

References

Kim I.-G.,et al.Biochim. Biophys. Acta 1359:181-186(1997).
Cheng L.J.,et al.Life Sci. 71:2741-2757(2002).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Katagiri T.,et al.Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS16327
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