|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Rabbit, Sheep, Horse, Bovine, Dog|
|Dilution||IHC-P (5 µg/ml), WB (1:2000-1:10000),|
|Other Names||Acetyl-CoA carboxylase 1, ACC1, 220.127.116.11, ACC-alpha, Biotin carboxylase, 18.104.22.168, ACACA, ACAC, ACC1, ACCA|
|Target/Specificity||Region between residue 2333 and the C-terminus (residue 2383) of human acetyl-Coenzyme A carboxylase alpha using the numbering given in entry NP_942131.1 (GeneID 31).|
|Reconstitution & Storage||Store at 2-8°C for up to 1 year.|
|Precautions||Acetyl-CoA Carboxylase / ACC Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ACAC, ACC1, ACCA|
|Function||Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.|
|Tissue Location||Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver|
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Provided below are standard protocols that you may find useful for product applications.
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Abu-Elheiga L.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:4011-4015(1995).
Mao J.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:7515-7520(2003).
Sinilnikova O.M.,et al.Carcinogenesis 25:2417-2424(2004).
Travers M.T.,et al.Biochim. Biophys. Acta 1634:97-106(2003).
Travers M.T.,et al.Genomics 85:71-84(2005).
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