|Application ||WB, IHC-P, IP|
|Reactivity||Human, Mouse, Bovine|
|Dilution||IHC-P (5 µg/ml), IP (2-10 µg/mg lysate), WB (1:1000-1:5000)|
|Other Names||Myoferlin, Fer-1-like protein 3, MYOF, FER1L3, KIAA1207|
|Target/Specificity||Region between residue 700 to 750 of human Myoferlin using the numbering given in entry NP_038479.1 (GeneID 26509).|
|Reconstitution & Storage||Store at 2-8°C for up to 1 year.|
|Precautions||MYOF / Myoferlin Antibody (aa700-750) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity).|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Nucleus membrane; Single-pass type II membrane protein Cytoplasmic vesicle membrane; Single-pass type II membrane protein. Note=Concentrated at the membrane sites of both myoblast- myoblast and myoblast-myotube fusions. Detected at the plasmalemma in endothelial cells lining intact blood vessels (By similarity) Found at nuclear and plasma membranes. Enriched in undifferentiated myoblasts near the plasma membrane in puncate structures.|
|Tissue Location||Expressed in myoblast and endothelial cells (at protein level). Highly expressed in cardiac and skeletal muscles. Also present in lung, and at very low levels in kidney, placenta and brain.|
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Provided below are standard protocols that you may find useful for product applications.
Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity).
Davis D.B.,et al.Hum. Mol. Genet. 9:217-226(2000).
Britton S.,et al.Genomics 68:313-321(2000).
Nagase T.,et al.DNA Res. 6:337-345(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Deloukas P.,et al.Nature 429:375-381(2004).
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