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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RANBP2 / TRP1 Antibody (aa1050-1100)   

RANBP2 / TRP1 Antibody (aa1050-1100)

Rabbit Polyclonal Antibody

     
  • WB - RANBP2 / TRP1 Antibody (aa1050-1100) ALS16332
    Detection of Mouse RanBP2 by Western Blot.
  • IHC - RANBP2 / TRP1 Antibody (aa1050-1100) ALS16332
    Anti-RANBP2 / TRP1 antibody IHC staining of human testis.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession P49792
Reactivity Human, Mouse, Rat, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 358kDa
Dilution IHC-P (1:100), IP (2-5 µg/mg lysate), WB (1:2000-1:10000)
Additional Information
Gene ID 5903
Other Names E3 SUMO-protein ligase RanBP2, 6.3.2.-, 358 kDa nucleoporin, Nuclear pore complex protein Nup358, Nucleoporin Nup358, Ran-binding protein 2, RanBP2, p270, RANBP2, NUP358
Target/Specificity Region between residue 1050 and 1100 of human RAN binding protein 2 using the numbering given in entry NP_006258.3 (GeneID 5903).
Reconstitution & Storage Store at 2-8°C for up to 1 year.
PrecautionsRANBP2 / TRP1 Antibody (aa1050-1100) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RANBP2
Synonyms NUP358
Function E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726).
Cellular Location Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Nucleus envelope. Note=Detected in diffuse and discrete intranuclear foci (PubMed:11839768). Cytoplasmic filaments (PubMed:7775481).
Volume 50 µl
Research Areas
Citations (0)

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Background

E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB.

References

Wu J.,et al.J. Biol. Chem. 270:14209-14213(1995).
Yokoyama N.,et al.Nature 376:184-188(1995).
Hillier L.W.,et al.Nature 434:724-731(2005).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Beddow A.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:3328-3332(1995).

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Discontinued
Cat# ALS16332
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