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ACACB / ACC2 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | O00763 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 277kDa |
| Dilution | ELISA (1:16000), IHC-P (5 µg/ml), |
| Gene ID | 32 |
|---|---|
| Other Names | Acetyl-CoA carboxylase 2, 6.4.1.2, ACC-beta, Biotin carboxylase, 6.3.4.14, ACACB, ACC2, ACCB |
| Target/Specificity | Mouse ACACB / ACC2. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | ACACB / ACC2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ACACB (HGNC:85) |
|---|---|
| Synonyms | ACC2, ACCB |
| Function | Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:19900410, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). |
| Cellular Location | Mitochondrion. |
| Tissue Location | Widely expressed with highest levels in heart, skeletal muscle, liver, adipose tissue, mammary gland, adrenal gland and colon (PubMed:9099716). Isoform 3 is expressed in skeletal muscle, adipose tissue and liver (at protein level) (PubMed:19190759). Isoform 3 is detected at high levels in adipose tissue with lower levels in heart, liver, skeletal muscle and testis (PubMed:19190759) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity).
References
Abu-Elheiga L.,et al.J. Biol. Chem. 272:10669-10677(1997).
Cheng D.,et al.Protein Expr. Purif. 51:11-21(2007).
Peng X.R.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Mao J.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).
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