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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ACACB / ACC2 Antibody (Internal)   

ACACB / ACC2 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - ACACB / ACC2 Antibody (Internal) ALS16336
    Anti-ACACB / ACC2 antibody IHC staining of human adrenal.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession O00763
Reactivity Human, Mouse, Rat, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 277kDa
Dilution ELISA (1:16000), IHC-P (5 µg/ml),
Additional Information
Gene ID 32
Other Names Acetyl-CoA carboxylase 2, 6.4.1.2, ACC-beta, Biotin carboxylase, 6.3.4.14, ACACB, ACC2, ACCB
Target/Specificity Mouse ACACB / ACC2.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsACACB / ACC2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACACB
Synonyms ACC2, ACCB
Function Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity).
Cellular Location Mitochondrion. Nucleus. Endomembrane system Note=May associate with membranes
Tissue Location Widely expressed with highest levels in heart, skeletal muscle, liver, adipose tissue, mammary gland, adrenal gland and colon (PubMed:9099716). Isoform 3 is expressed in skeletal muscle, adipose tissue and liver (at protein level) (PubMed:19190759). Isoform 3 is detected at high levels in adipose tissue with lower levels in heart, liver, skeletal muscle and testis (PubMed:19190759).
Research Areas
Citations (0)

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Background

Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity).

References

Abu-Elheiga L.,et al.J. Biol. Chem. 272:10669-10677(1997).
Cheng D.,et al.Protein Expr. Purif. 51:11-21(2007).
Peng X.R.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Mao J.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).

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$ 395.00
Cat# ALS16336
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