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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   LAMP2 / CD107b Antibody (clone H4B4)   

LAMP2 / CD107b Antibody (clone H4B4)

Mouse Monoclonal Antibody

     
  • IHC - LAMP2 / CD107b Antibody (clone H4B4) ALS16339
    Anti-LAMP2 / CD107b antibody IHC staining of human kidney.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, IHC-Fr, Flo
Primary Accession P13473
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names H4B4
Calculated MW 45kDa
Dilution ICC, IHC-P (10 µg/ml),
Additional Information
Gene ID 3920
Other Names Lysosome-associated membrane glycoprotein 2, LAMP-2, Lysosome-associated membrane protein 2, CD107 antigen-like family member B, CD107b, LAMP2
Target/Specificity Monoclonal antibody H4B4 recognizes CD107b / LAMP-2, an extensively glycosylated 100-120 kD widely expressed lysosome-associated protein.
Reconstitution & Storage Store at 2-8°C. Do not freeze.
PrecautionsLAMP2 / CD107b Antibody (clone H4B4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LAMP2
Function Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
Cellular Location Cell membrane; Single-pass type I membrane protein {ECO:0000255|PROSITE- ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Endosome membrane; Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Lysosome membrane {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane
Tissue Location Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver
Volume 50 µl
Research Areas
Citations (0)

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Background

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.

References

Fukuda M.,et al.J. Biol. Chem. 263:18920-18928(1988).
Sawada R.,et al.J. Biol. Chem. 268:9014-9022(1993).
Fritz G.,et al.J. Biol. Chem. 268:21102-21112(1993).
Konecki D.S.,et al.Biochem. Biophys. Res. Commun. 205:1-5(1994).
Konecki D.S.,et al.Biochem. Biophys. Res. Commun. 215:757-767(1995).

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$ 395.00
Cat# ALS16339
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