|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500-1:1000)|
|Other Names||Flotillin-2, Epidermal surface antigen, ESA, Membrane component chromosome 17 surface marker 1, FLOT2, ESA1, M17S1|
|Target/Specificity||Flotillin-2 antibody detects endogenous levels of Flotillin-2.|
|Reconstitution & Storage||Store at -20°C.|
|Precautions||FLOT2 / Flotillin 2 Antibody (aa95-144) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.|
|Cellular Location||Cell membrane; Peripheral membrane protein Membrane, caveola; Peripheral membrane protein. Endosome. Membrane; Lipid- anchor. Note=Membrane-associated protein of caveolae|
|Tissue Location||In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes|
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May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
Zody M.C.,et al.Nature 440:1045-1049(2006).
Schroeder W.T.,et al.J. Biol. Chem. 269:19983-19991(1994).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Gorbea C.,et al.J. Biol. Chem. 285:31616-31633(2010).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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