|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500-1:1000)|
|Other Names||DCC-interacting protein 13-alpha, Dip13-alpha, Adapter protein containing PH domain, PTB domain and leucine zipper motif 1, APPL1|
|Target/Specificity||APPL1 Antibodyantibody detects endogenous levels of APPL1.|
|Reconstitution & Storage||Store at -20°C.|
|Precautions||APPL1 / APPL Antibody (aa111-160) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway.|
|Cellular Location||Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear Translocated into the nucleus upon release from endosomal membranes following internalization of EGF|
|Tissue Location||High levels in heart, ovary, pancreas and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.
Mitsuuchi Y.,et al.Oncogene 18:4891-4898(1999).
Liu J.,et al.J. Biol. Chem. 277:26281-26285(2002).
Nagase T.,et al.DNA Res. 7:65-73(2000).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Miaczynska M.,et al.Cell 116:445-456(2004).
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