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NUMA1 / NUMA Antibody (aa315-364)

Rabbit Polyclonal Antibody

     
  • WB - NUMA1 / NUMA Antibody (aa315-364) ALS16348
    Western blot of the lysates from K562 cells using NUMA1 antibody.
  • IHC - NUMA1 / NUMA Antibody (aa315-364) ALS16348
    Anti-NUMA1 / NUMA antibody IHC staining of human breast.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q14980
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 238kDa
Dilution ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 4926
Other Names Nuclear mitotic apparatus protein 1 {ECO:0000312|HGNC:HGNC:8059}, NuMA protein, Nuclear matrix protein-22, NMP-22, SP-H antigen, NUMA1 (HGNC:8059)
Target/Specificity NUMA1 Antibodyantibody detects endogenous levels of NUMA1.
Reconstitution & Storage Store at -20°C.
PrecautionsNUMA1 / NUMA Antibody (aa315-364) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NUMA1 (HGNC:8059)
Function Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume (PubMed:10075938). Required for maintenance and establishment of the mitotic spindle poles during symmetric cell divisions, functioning as a tether linking bulk microtubules of the spindle to centrosomes (PubMed:7769006, PubMed:11956313, PubMed:26195665). Also required for proper alignment of the mitotic spindle during asymmetric cell divisions (PubMed:21816348).
Cellular Location Nucleus matrix. Chromosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Resides in the nuclear matrix during interphase. Dissociates from condensing chromosomes during early prophase and relocates to the spindle poles via dynein/dynamin association; it remains there until the anaphase onset. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident. CCSAP is essential for its centrosomal localization (PubMed:26562023). Isoform Numa-s: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, mainly clustered at the centrosomal region in the cytosol. After entry into mitosis, detected at mitotic spindle poles
Volume 50 µl
Research Areas
Citations (0)

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Background

Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.

References

Yang C.H.,et al.J. Cell Biol. 116:1303-1317(1992).
Compton D.A.,et al.J. Cell Biol. 116:1395-1408(1992).
Maekawa T.,et al.J. Cell Sci. 105:589-600(1993).
Taylor T.D.,et al.Nature 440:497-500(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16348
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