|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500-1:1000)|
|Other Names||AarF domain-containing protein kinase 4, 2.7.11.-, ADCK4|
|Target/Specificity||ADCK4 Antibodyantibody detects endogenous levels of ADCK4.|
|Reconstitution & Storage||Store at -20°C.|
|Precautions||ADCK4 Antibody (aa6-55) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:24270420). Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration (PubMed:24270420).|
|Cellular Location||Mitochondrion membrane; Single-pass membrane protein. Cytoplasm, cytosol. Cell membrane|
|Tissue Location||Widely expressed, including renal podocytes.|
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Provided below are standard protocols that you may find useful for product applications.
May play a role in CoQ10 (COQ10A and/or COQ10B) biosynthesis, which is required for podocyte migration.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Greenman C.,et al.Nature 446:153-158(2007).
Ashraf S.,et al.J. Clin. Invest. 123:5179-5189(2013).
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