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ARHGEF5 Antibody (aa1251-1300)

Rabbit Polyclonal Antibody

     
  • WB - ARHGEF5 Antibody (aa1251-1300) ALS16353
    Western blot of the lysates from K562 cells using ARHGEF5 antibody.
  • IHC - ARHGEF5 Antibody (aa1251-1300) ALS16353
    Anti-ARHGEF5 antibody IHC staining of human small intestine.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q12774
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 177kDa
Dilution ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 7984
Other Names Rho guanine nucleotide exchange factor 5, Ephexin-3, Guanine nucleotide regulatory protein TIM, Oncogene TIM, Transforming immortalized mammary oncogene, p60 TIM, ARHGEF5, TIM
Target/Specificity ARHGEF5 Antibodyantibody detects endogenous levels of ARHGEF5.
Reconstitution & Storage Store at -20°C.
PrecautionsARHGEF5 Antibody (aa1251-1300) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARHGEF5
Synonyms TIM
Function Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity).
Cellular Location Cytoplasm. Nucleus. Cell projection, podosome {ECO:0000250|UniProtKB:E9Q7D5}
Tissue Location Ubiquitously expressed with highest levels in placenta. High levels are also found in colon, kidney, trachea, prostate, liver, pancreas, pituitary gland, thyroid gland and mammary gland. In fetal tissues, expressed at high levels in kidney, lung and liver (PubMed:15601624). Expressed at low levels in lung and heart (PubMed:14662653).
Volume 50 µl
Research Areas
Citations (0)

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References

Chan A.M.-L.,et al.Oncogene 9:1057-1063(1994).
Jikuya H.,et al.Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 424:157-164(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Sahin M.,et al.Neuron 46:191-204(2005).

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$ 395.00
Cat# ALS16353
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